The aim of this systematic review was to present existing CAD/CAM materials on post-core restorations in terms of content, materials, fabrications, and performance. The research methodology for this work followed PRISMA guidelines and strategy by integrating a refined methodical search approach, setting the inclusion and exclusion criteria, and specifying certain requirements based on which the relevant literature will be selected for the synthesis of results. Three independent reviewers conducted database searches to obtain literature from the years 2013 to 2024, which was later summarized. A total of 185 titles were obtained through electronic database searches. Regarding the post and core restoration,  advancements have been made in both conventional and CAD/CAM technologies. To date, several methodologies have been published regarding the CAD/CAM post-core restoration of endodontically treated teeth using direct and indirect methods.