For decades, implant placement protocols and implant loading protocols were addressed independently from one another. With the healing of the alveolar socket post-extraction, the implant placement protocol and the surgical technique are determining factors for selection of an appropriate implant loading protocol; these should be considered as codependent variables. The objectives of the study were to highlight factors influencing the implant placement and loading protocol. Material and methods. The retrospective study included patients presented for teeth extraction and oral rehabilitation treatment plan that included implant restorations between October 2020 and October 2022. Factors influencing implant placement and loading protocol were analyzed for each case. Representative cases were presented with details. Results. 10 clinical cases were included in the study, in which implanto-prosthetic treatment was performed using different insertion protocols. Three representative cases were presented. Conclusions. Implant insertion protocols are closely related to multiple factors, so the clinician nowadays must carefully decide the time elapsed from tooth extraction to the moment of dental implant insertion. The insertion protocol should be chosen only if the factors influencing that protocol led to the success of the implant-prosthetic treatment.